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Oleamide dosage? What would be a good dosage of Oleamide I'm using it to potentially help with intrusive thoughts which may be caused by low cannabinoid receptor activity? Higher amounts tend to cause drowsiness. Absorption is possibly improved by supplementing together with a bit of olive oil and lecithin. Would it be better to take it sublingually? At what dosage do negatives like difficulty moving or waking up occur? Did it relly work as you say, you sure it wasn't placebo? I have read many reporweres saying that there were basically no noticable effects and the people that say it worked say the effects very mild to possibly placebo So what are your thoughts? Still love it, gives some great REM quality to sleep that makes dreams pretty lucid. Love taking a shot of it mixing the little pellets into a glass of water and drinking them before my second sleep really gets my dreams going. It's a dream, can't tell ya. Usually wake up more rested with a little less sleep from oleamide nights. My girlfriend thinks so too, we both usually take it, and she agreesher dreams are usually more lucid, feeling more well rested. Also provides a calm somewhat akin to theanine, which could also be placebo but whatever. Usually doses under mg. And usually higher doses like a gram and such are even more sedating. I discovered Oleamide listening to a tech podcast of all places. The guy says he takes a gram every night! My order arrived today from LM, hoping for a good night sleep. I'll probably start with mg and see how that works. I understand it's quite short acting, so taking more probably won't hurt if it doesn't seem to be working. I've been taking a gram a night of oleamide for about 3 months.
Oleamide dosage for sleepOleamide is an amide of the fatty acid oleic acid. It is an endogenous substance: it occurs naturally in the body of animals. It accumulates in the cerebrospinal fluid during sleep deprivation and induces sleep in animals. The mechanism of action of oleamide's sleep inducing effects is an area of current research. It is likely that oleamide interacts with multiple neurotransmitter systems. In addition, oleamide potentiates several serotonin receptors and the GABA A receptor, and inhibits gap junction communication. Synthetically produced oleamide has a variety of industrial uses including as a slip agent, a lubricantand a corrosion inhibitor. Oleamide was originally characterized as an endogenous bioactive substance, isolated from the cerebrospinal fluid of sleep deprived cats. Oleamide was found by researchers to be leaking out of polypropylene plastics used in laboratory experiments, affecting experimental results. There is no documented evidence of Oleamide being used specifically as a recreational drug. However, it was found in large quantities in the smoking blends "Smoke" and "Skunk" alongside the synthetic cannabinoid JWH . Jump to: navigationsearch. Oleamide  File:Oleamide. Z -Octadecenamide. Other names. See also Template: Neuropeptides. Personal tools Log in. CAS number. EC number. Script error: No such module "collapsible list". Molecular formula. Molar mass. Melting point. Boiling point. Solubility in water. NFPA Flash point. Infobox references.
Oleamide redditMy first experience with oleamide. I decided to grab some of this to get the free shipping through ND. I didn't expect much as there seems to be very few reports and even less stating an effect. I think its important to mention that I've been consuming cannabis for approximately 9 years, more recently mostly at night to help me fall asleep. My sleep quality has been pretty bad the last few months due to stress and a few other personal issues. I typically will end up taking a sleeping pill once or twice every two weeks just to feel like I got a restful night. I put it under my tongue for about 10 minutes and to my surprise most dissolved but it was horrible tasting. After I fell asleep is when it truly shined. Typically I'll sleep for an hour and a half or sometimes 3 hours and then wake up reposition and try to go back to sleep. And then at some point in the night I'll get up and feed my cat. Last night I slept four and a half hours straight till my cat woke me up for food and then went back to sleep without having to smoke for another four and a half. I feel so rested and great that I'm truly stunned. Highly recommend any cannabis users struggling to sleep give this a try. Since you are a regular cannabis user, your cannabinoid receptors are likely downregulated a fair bit. So you will need more oleamide compared to a non cannabis user to have the same effect. My hypothesis behind given I'm not mistaken is that the recepors don't get propperly recycled and thus stay in such a conformation and this maybe beacuse the body avoids to downregulate excitotoxcicity protecting receptors. I first bought oleamide in It is indispensable, especially if you're trying to not become dependent on something to sleep. Cycle it with tetrahydropalmatine and melatonin. I've come close to ordering that stuff before WAY WAY back in the day off LiftMode but never did because all the reports I read online said it was pretty useless or very very subtle at best. So you honestly felt an effect after taking it or you just slept better? I think you will have to try it more then one night to come to a conclusion on its effectivness at keeping you asleep longer ND's stuff is the real deal. According to the reference, trans-Oleamide has effects too - although it's correct cis-Oleamide is the more active isomer:. It is clear, therefore, that trans-oleamide is biologically active, although less so than the cis isomer. Characterizing trans-Oleamide as inactive or worthless is an oversimplification.
Oleamide health benefitsIt seems like there is no agreement if this is a cannabinoid or not. I'm going to look for a source that it is a cannabinoid. If no one can fine a citation by April we can remove it. It is definitly no terpene and is absolutly not related to Cannabinoids so we should change this. As I've pointed out before, the evidence that Oleamide activates CB receptors is extremely sparse. The one paper that is cited suggesting that is accompanied by a commentary in the SAME issue of the SAME journal that says this: "A wider interpretation that the compound acts as an endocannabinoid in vivo is perhaps premature. The in vivo data so far reported in the literature give conflicting information regarding the contribution of CB1 receptors at least for some of the actions of exogenously applied oleamide see Leggett et al, and there is, to my knowledge, no evidence to indicate that the compound is involved in the endocannabinoid tone that is believed to modulate neurotransmitter release, neuroprotection and other important physiological events. Roadnottaken talk6 August UTC. I agree. This should properly be categorized as a Eicosanoid. The article should include the fact that JWH and oleamide are the main active ingredients in Organic Worx Smoke, which makes me worried since surely it can't be safe to smoke it? Surely oleamide the chemical was known before Cravatt's work? MeSH has had an oleamide entry since I have removed the "Recreation use" section: There is no documented evidence of Oleamide being used specifically as a recreational drug. However, it was found in large quantities in the smoking blends "Smoke" and "Skunk" alongside the synthetic cannabinoid. The purpose of the addition of oleamide to these blends is unclear. I don't think it is necessary to have a section for recreational use that states that there is no evidence of recreational use. Secondly, oleamide's presence in "smoking blends" is just trivia when the reason it is there is "unclear". I see the information as more than just trivia. Identifying the ingredients in these blends is very important, and information on their ingredients is quite hard to come by obviously the vendors try to keep them secret. These products are used by hundreds of thousands if not millions worldwide, most of them clueless as to what they contain. It's not as if the article is overly cluttered. Including this information won't do any harm, and from searching through discussion forums I have seen this little snippet of information do a lot of good. Living under a rock talk5 September UTC. I have just added archive links to one external link on Oleamide. Please take a moment to review my edit. I made the following changes:. As of February"External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot.
Oleamide, also known as Cerebrodiene, is an organic compound and the primary amide derived from oleic acid ODA octadecanoamide. Oleic Acid is an omega-9 fatty acid from olive oil. Oleamide is colorless and has a waxy solid texture. Oleamide was first isolated from the spinal fluid of sleep-deprived cats. Sometimes Oleamide is classified as a fatty acid primary amide FAPA and occurs naturally in animals and accumulates in the cerebrospinal fluid when the body is experiencing sleep deprivation. The natural occurrence of Oleamide in human serum was first reported in Oleamide is a natural metabolite of Oleic acid and has been used in traditional Chinese practices for sleep support. The first use of Oleamide in traditional Chinese practices started with the Jujube fruit where its usage dates as far back as years. This later sparked research in which it was found that Oleamide naturally occurs in Jujube plants. Further research has shown that Oleamide appears to be synthesized in humans from ammonia and oleic acid. Additionally, it has been determined that Oleamide is structurally similar to anandamide. Anecdotal reports suggest that their Oleamide experiences improved their sleep habits. Some research suggests that Oleamide effects can promote healthy levels of neuroinflammation by acting on the CB2 cannabinoid 2 receptor in high concentrations. Thus suggesting that this compound has potential to promote cellular health and promote healthy stress levels. Studies have shown serotoninergic effects of Oleamide. It makes the 5-HT2A serotonin receptors more sensitive without necessarily influencing the normal signaling process. It acts as agonist on the receptor when no serotonin is present and produces serotonin like effects at a lower intensity. As a dietary supplement, take mg of Oleamide times daily. To gain more insight, read the Oleamide experiences and reviews below. Nootropics Depot offers gram jars of high quality Oleamide powder. Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Bought some of this because I was desperate for sleep.